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KMID : 0378019820250100085
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New Medical Journal
1982 Volume.25 No. 10 p.85 ~ p.90
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Treatment of Gonarthrosis with Heterogenous Immunoglobulin "Artroglobina"
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Abstract
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Mechanical wear and tear has been thought to be the main cause of osteoarthritis. But recently, immunological implication in the pathogenesis of osteoarthritis began to be acknowledged. Cooke et. al (1980) demonstrated immunoglobulins, Ig A and Ig G in osteoarthritic cartilage. Mankin (1981) stated that immunological implication is one of the possible, etiological mechanism in the development of osteoarthritis. Thus, it is not surprising for a physician to use an immunological method in the treatment of osteoarthritis, while for this condition, analgesics, steroids and NSAIDs have been prescribed commonly only for relieving and/or alleviation of, the arthritic symptoms.
The present authors administered heterogenous immunoglobulin "-Artroglobina" (Morrith? Spain) to.56 patients having gonarthrosis at out-patient department of Orthopedic Surgery, ,Kang-Nam St. Mary´s Hospital, Seoul, and its efficacy was evaluated clinically by patient´s: statement and physical findings.
The results obtained were as follows;
1. Pain relief more than moderate degree was obtained in 46 out, of 58 cases (85.7%) . Na, significant pain relief was obtained in eight cases (14.3%).
2. The severity of joint and patellar tenderness was minimized (more than moderate degree) in four fifths of patients.
3. Among 22 patients with joint effusion, effusion was reduced in 15 cases (68.2%) .
4. Pain relief was observed after average 2.6 course of artroglobina administration. Changes in the severity of joint and patellar tenderness and knee joint effusion were observed later than relief of pain.
5. Ultimate over-all excellent and good results were obtained in 31 out of 56 cases (55.4%), and moderate improvement in 17 cases (30.4%). No beneficial effect was obtained in 8 cases (14.3%) by the Artroglobina. These 8 cases had severe osteoarthritis.
6. No adverse reaction was observed except transient changes in bowel habit in 2 cases.
These results suggest that Artroglobina is a safe and effective drug in the treatment of osteoarthritis, and present authors highly recommend it´s clinical use in the treatment of the early and moderately advanced osteoarthritis.
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